SBM 202 | Course Introduction and Application Information

Course Name
Scientific Basis of Medicine IV
Code
Semester
Theory
(hour/week)
Application/Lab
(hour/week)
Local Credits
ECTS
SBM 202
Spring
16
4
18
18

Course Objectives In this course; relevant topics in pharmacology, medical microbiology, immunology, basic pathology and epidemiology will be discussed. This course aims to form a basis for the pathological phase where pathophysiological mechanisms of diseases, diagnosis and treatment will be learned.
Learning Outcomes The students who succeeded in this course;
  • Explain the phases of drug development and their features, classification of the drugs; the drug and the body interaction and the factors altering this interaction
  • Describe the major determinants of infectious diseases, the links in the “chain of infection” and the role of correct diagnosis, treatment and appropriate infection control measures for breaking the links
  • Define the main microbiological features of medically important pathogens
  • Expound molecular and cellular components and pathways of innate and adaptive immune responses that protect an organism from infections or cancer
  • Explain the causes and mechanisms of reversible, irreversible cell injury and cellular adaptation
  • Describe the mechanisms of inflammation, define its types and associated morphologic features
  • Define the mechanisms of tissue repair, the factors influencing the tissue repair, the differences between primary and secondary wound healing
  • Explain the mechanisms of hemodynamic disorders, thrombus, embolism, infarction and their morphological features
  • Define the shock types, their pathogenesis, morphological and clinical features
  • Explain the basic processes underlying the transformation of a normal cell to its malignant form, and the consequences of malignant transformation on the cellular and organism level
  • Define the basic nomenclature, morphologic characteristics, grading and staging of tumors, and the principles of tumor diagnosis and treatment.
  • Explicate the basic principles of imaging and clinical laboratory methods and their clinical applications.
  • Define the characteristics of different stages of healthy life from childhood to the end-of-life, the lifecycle related health risks and preventive measures
  • Explain how the basic concepts in epidemiology and biostatistics are applied to causal factors for health problems.
  • Evaluate their own reflection, self-assessment and feedback skills, identify their strengths and weaknesses, create a development plan for the aspects that need to be improved, and present the portfolio evidences in a file.
Course Description • Basic principles of pharmacology including pharmacokinetics and pharmacodynamics • Basic concepts of infection, infection control, pathogenesis and microbiology of medically important microorganisms • Molecular and cellular components and pathways of innate and adaptive immune responses against infections or cancer. • Injurious agents interfering with homeostasis • The concept and mechanisms of disease and corresponding alterations occurring in the body • The impact of biopsychosocial and cultural factors on human health • General features of the related laboratory and clinical diagnostic procedures. • Changing health needs and challenges along the human life cycle and prepare them to anticipate and address the health issues at different stages of life in the clinical setting. • Basic principles of therapy.

 



Course Category

Core Courses
X
Major Area Courses
Supportive Courses
Media and Management Skills Courses
Transferable Skill Courses

 

WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES

Week Subjects Related Preparation
1 Pharmacology, Infection Basics, Introduction to Immune response • Basic and Clinical Pharmacology, McGraw-Hill Medical, Chapters 1-5, 14th Ed. 2018. Bertram G. Katzung, https://accessmedicine.mhmedical.com/book.aspx?bookid=2249 • Goodman & Gilman’s Pharmacological Basis of Therapeutics, McGraw-Hill Medical, Chapters 1-7., 13th Ed. 2018, Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann https://accessmedicine.mhmedical.com/content.aspx?bookid=2189§ionid=172483986#1149954192 • Katzung & Trevor's Pharmacology: Examination & Board Review, Chapters 1-5, 12th Ed., 2019. Bertram G. Katzung, Marieke Kruidering-Hall, Anthony J. Trevor. https://accessmedicine.mhmedical.com/book.aspx?bookid=2465 • https://ieu.lecturio.com/#/course/c/6872/6660 (Pharmacokinetics and Pharmacodynamics) • https://ieu.lecturio.com/#/course/c/6872/6956 (Antimicrobial Pharmacology) • https://ieu.lecturio.com/#/course/c/6432 (Introduction to Microbiology) • https://accessmedicine.mhmedical.com/Book.aspx?bookid=2268 (Sherris Medical Microbiology, 7e) • https://accessmedicine.mhmedical.com/Book.aspx?bookid=2629 (Jawetz, Melnick & Adelberg’s Medical Microbiology, 28e) • https://accessmedicine.mhmedical.com/Book.aspx?bookid=2867 (Review of Medical Microbiology, 16e) • Abbas, Lichtman, Pillai Cellular and Molecular Immunology 8th Ed Elsevier Saunders, 2015 • Microbiology and Immunology McGraw Hill 2016
2 Pharmacology (Quantitative evaluation of drug –receptor interactions, Antimicrobials), Basic concepts in bacteriology, molecular basis of adaptive immunity, Research Information Management • https://ieu.lecturio.com/#/course/c/6432/8280 (Bacteria, videos 1- 8) • https://accessmedicine.mhmedical.com/Book.aspx?bookid=2268 (Sherris Medical Microbiology, 7e) • https://accessmedicine.mhmedical.com/Book.aspx?bookid=2629 (Jawetz, Melnick & Adelberg’s Medical Microbiology, 28e) • https://accessmedicine.mhmedical.com/Book.aspx?bookid=2867 (Review of Medical Microbiology, 16e) • Epidemiology, Evidence-based Medicine and Public Health, 6th edition. • Basic and Clinical Pharmacology, McGraw-Hill Medical, Chapters 43-47, 14th Edition. Bertram G. Katzung, 2018 https://accessmedicine.mhmedical.com/book.aspx?bookid=2249 • Goodman & Gilman’s Pharmacological Basis of Therapeutics, McGraw-Hill Medical, Chapters 56-60, 13th Edition, Laurence L. Brunton, Randa Hilal-Dandan, Björn C. Knollmann, 2018 https://accessmedicine.mhmedical.com/content.aspx?bookid=2189§ionid=172483986#1149954192 • Katzung & Trevor's Pharmacology: Examination & Board Review, Chapters 43-46, 12th Edition. Bertram G. Katzung, Marieke Kruidering-Hall, Anthony J. Trevor, 2019. https://accessmedicine.mhmedical.com/book.aspx?bookid=2465
3 Molecular basis of adaptive immunity, Fungal infections, Diagnostic sensitivity (RIM), Diagnosis of bacterial infections Lecture notes and references
4 Antibodies, Mycology, epidemiology, Antifungals, Bayesian theory (RIM), Pharmacology. Discussion sessions & Midterm Exam I Lecture notes and references
5 Bacteriology, adaptive immunity Lecture notes and references
6 Bacteriology (Testing), Viral pathogenesis, Adaptive Immunity, Pharmacology Lecture notes and references
7 Bacteriology, Pharmacology Lecture notes and references
8 Bacteriology, Hypothesis tests (RIM), Reference intervals (Lab Medicine). Discussion Sessions & Midterm Exam 2 Lecture notes and references
9 DNA damage, Aging, Cell signaling and disease (Medical Biol), Regression analyses (RIM), Biochemical mechanisms of diseases (Biochem), Cellular growth and differentiation (Pathology), Inflammation and Immunity (Immunology), Lecture notes and references
10 5-day (April 08-12) National Holiday
11 Inflammation, Wound healing, Tissue repair Adaptation and cell injury(Pathology), NSAIDs (Pharmacology), Genetic factors & thrombosis (Medical Biol) Lecture notes and references
12 Hypovolemic shock (Gen. Surgery), Virology (Microbiol), Embolism (Pathology) Lecture notes and references
13 Wound healing and oxydative stress (Biochem), Autoimmunity (Immunology), Autoimmune disease (Pathology), Virology (Microbiology), Antivirals (Pharmacology) Midterm Exam 3 Lecture notes and references
14 Immunodefficiencies, vaccinations (Immunology), Discussion sessions. Lecture notes and references
15 Oncoviruses (Microbiology), Immunosuppressants (Pharmacology), Case control studies (RIM), Carcinogenesis (Medical Biol, Histology & Embriology, Immunology) Lecture notes and references
16 Carcinogenesis (Immunology, Pathology, Pathology), Infectious diseases (Public Health) Lecture notes and references
17 Parasitology
18 Growth and development (Pediatrics), Carcinogenesis models (Immunology), Lab Medicine, Pathology practicals, Psychosocial development (Psychiatry, Internal Medicine), Chemotherapeutics (Pharmacology), Nutrition (Pediatrics, Dietetics), Evaluation of well child (Pediatrics), Molecular diagnostics (Lab Medicine) Midterm Exam 4

 

Course Notes/Textbooks
Suggested Readings/Materials

 

EVALUATION SYSTEM

Semester Activities Number Weigthing
Participation
Laboratory / Application
Field Work
Quizzes / Studio Critiques
Portfolio
1
10
Homework / Assignments
1
10
Presentation / Jury
Project
Seminar / Workshop
Oral Exams
Midterm
4
40
Final Exam
1
40
Total

Weighting of Semester Activities on the Final Grade
6
60
Weighting of End-of-Semester Activities on the Final Grade
1
40
Total

ECTS / WORKLOAD TABLE

Semester Activities Number Duration (Hours) Workload
Theoretical Course Hours
(Including exam week: 18 x total hours)
18
16
288
Laboratory / Application Hours
(Including exam week: '.18.' x total hours)
18
4
72
Study Hours Out of Class
18
5
90
Field Work
0
Quizzes / Studio Critiques
0
Portfolio
1
10
10
Homework / Assignments
1
10
10
Presentation / Jury
0
Project
0
Seminar / Workshop
0
Oral Exam
0
Midterms
4
10
40
Final Exam
1
30
30
    Total
540

 

COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP

#
Program Competencies/Outcomes
* Contribution Level
1
2
3
4
5
1

Knowledge for Practice: Uses knowledge in biomedical, clinical, epidemiological, biostatistics, biomedical informatics, social and behavioral sciences for the prevention, diagnosis, treatment and management of medical problems.

X
2

Information Management and Research: Uses the information generated through research and accessed from different sources in evidence-based patient management processes

X
3

Patient management: Provides patient-centered, holistic, safe, reliable and evidence-based health care for common health problems in the community, prioritizing health protection and improvement*.

4

Patient and employee safety: Provides health services by considering the health and safety of patients and employees.

X
5

Protection and promotion of health: Prioritizes protecting and improving the health of individuals and society in the provision of health services under usual/unusual situations. Performs clinical and public health practices in a holistic and competent manner

6

Adherence to ethical principles: Fulfills the duties and obligations within the framework of ethical principles and, rights and legal responsibilities required by the profession.

7

Professional competence: Provides a high-quality healthcare service that prioritizes patient safety. While applying the profession, he/she knows his/her limits, evaluates his/her own performance, determines the aspects that need to be developed and improves them within a plan

X
8

Professional virtues: Avoid behaviors that will undermine the public's trust in medicine. S/he approaches her/his patients with compassion and care without discrimination, and puts their welfare ahead of her/his own interests

9

A healthy physician- a healthy society: Gives importance to his/her personal health, safety and appearance, sets an example for his/her colleagues and society by taking the necessary precautions.

10

Planetary health and healthy lifestyles: Considering the effects of the resources offered by our planet on individual and public health, he/she accepts promoting healthy lifestyles and eliminating the factors that negatively affect health his/her duty.

X
11

Protecting and improving health as a social responsibility: Accepts protection and improvement of public health as a social responsibility, identifies the primary health problems of the society served and produces solutions.

12

Health policies: Evaluates the impact of health policies on the health indicators of individuals and society, and advocates increasing the quality of health services.

13

Change management: Systematically identifies and manages the issues/processes and the necessary resources that require change in order to provide quality, safe and cost-effective health care.

14

Personal qualifications: Provides evidence exerting that he/she is equipped enough to lead changes to make healthcare more qualified, safe and cost-effective

15

Communication skills: Uses verbal and non-verbal communication effectively. Communicates with patients in a way that makes them feel understood, with active listening behaviors (eye contact, affirmation, summarizing, etc.)

16

Communication with patients and their relatives: Establishes supportive relationships with patients and their families that contribute positively to the treatment process

17

Communication for qualified and safe health care: Communicates with patients, their relatives, health workers, other professional groups, institutions and organizations in a clear, understandable and professional manner that will minimize patient safety risks and increase the quality of health care. Considers and protects patient privacy and data security in all communications.

18

Explains the place and importance of scientific research and evidence in providing qualified and safe health care. Analyzes the health problems in the society s/he serves with scientific methods. Reaches information to access evidence. Uses the information analyzed and the evidence accessed from the literature to provide more qualified and safer health care

19

Reflection: Using reflective approaches, he/she questions his/her professional performance, identifies areas that require improvement, and develops his/her professional knowledge and skills by identifying learning needs.

X
20

Stress management: Explains and applies strategies for coping with stress and preventing burnout

*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest

 


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