SBM 101 | Course Introduction and Application Information - Medicine

Course Name

Scientific Basis of Medicine I

Code	Semester	Theory (hour/week)	Application/Lab (hour/week)	Local Credits	ECTS
SBM 101	Fall	12	4	14	16

Prerequisites	None
Course Language	English
Course Type	Required
Course Level	First Cycle
Mode of Delivery	-
Teaching Methods and Techniques of the Course	Discussion Group Work Problem Solving Case Study Q&A Simulation Application: Experiment / Laboratory / Workshop Lecture / Presentation
National Occupation Classification	-
Course Coordinator	Dr.Öğretim Üyesi Melis KARTAL YANDIM
Course Lecturer(s)	Doç. Dr. Ayşe Banu DEMİR Doç. Dr. Yasemin SEVAL ÇELİK Dr.Öğretim Üyesi Ali Burak ÖZKAYA Dr.Öğretim Üyesi Elif BARIŞ Dr.Öğretim Üyesi Hasan KAZDAĞLI Dr.Öğretim Üyesi Melis KARTAL YANDIM Dr.Öğretim Üyesi Merve ÖZGÜR ERAT Öğr.Gör.Dr. Alihan BULGURCU Prof. Dr. Gül AKDOĞAN Prof. Dr. Makbule İlgi ŞEMİN Prof. Dr. Metiner TOSUN Prof. Dr. Vissun Sevinç İNAN Prof. Dr. Yusuf Hakan ABACIOĞLU
Assistant(s)	-

Course Objectives	At the end of this semester, the students are expected to understand the relationship between the human being and its environment as well as the planet. To familiarize the students with the medical profession, introduce them to medical education, to start the concepts of physician responsibilities, professional values, ethics, professionalism and to lay down the foundations of skill training. The aim of this course is to give students awareness of protecting and developing health, giving awareness about the factors affecting human health and understanding the healthy life behaviors of the individual. In addition, the aim is for the students to meet the concept of measurement and medical terminology, to understand the structural organization of the human body, the building blocks of the human body and their basic features, cell structure and cell cycle, the mechanisms of interaction between the cell and other cells and the environment, the basic principles in metabolism, and to learn the concept of organ formation, early embryological development phases and the features inheritance
Learning Outcomes	The students who succeeded in this course; 1. Define the organization of the human body. 2. Define human's biological, psychological and social developmental stages. 3. Describe the common medical terms by looking at their prefixes, suffixes, and roots. 4. Describe the components and functions of the skeletal system. 5. Define the basic principles of methods used in medical laboratories within the framework of diagnostic medicine (imaging and laboratory medicine). 6. Explain the biological and chemical basis of life, its regulation, the structure of macromolecules and the structure-function relations. 7. Explain the functions and interactions of the cell as the basic vital form 8. Define the basic principles of cell bioenergetics, the pathways whereby nutritional fuels are converted into energy, and the role and mechanism of enzymes. 9. Explain the flow of genetic information (how protein synthesis from DNA occurs). 10. Explain the cell cycle and its control mechanisms. 11. Explain the mechanisms of intracellular and intercellular communication, how the cells respond to environmental stimuli and the causes and mechanisms of formation of bioelectric potentials. 12. Explain fertilization and the processes that occur during the first 8 weeks of embryonic development and the influencing factors. 13. Explain the features of tissue development and tissue types. 14. Explain the fundamentals and mechanisms of genetic variation, inheritance patterns and population genetics. 15. List the steps of critical and scientific thinking, explain how to access reliable sources and evaluate information sources using the steps of critical thinking. 16. She/he reflects on an example of a meaningful learning experience she/he chooses, where she/he determines learning needs and creates a plan for meeting those needs.
Course Description	Health is a phenomenon with biological, psychological and social components; so a physician who manages health, should be able see the individual as a biopsychosocial entity and recognize the complex relationship between the individual and society. This goal can only be achieved if the physicians know the society they serve. The organized educational activities in this course will facilitate the understanding of the organization of the human body, its basic building blocks and their properties, the concepts of cell biology, biochemistry and physiology and the formation of tissues and basic features of early embryonic development. The course consists of three main themes: 1. Biomedical sciences: The program is intertwined with cell/organ/system/concepts. The basic disciplines are the following: anatomy, biochemistry, biophysics, histology and embryology, immunology, medical biology and genetics, and physiology. 2. Research and information management: Consists of critical and scientific thinking components. 3. Laboratory medicine: Aims to convey to students the general principles and topics of laboratory medicine that will be of value to them in their future medical practice. Learning methods: Lectures, small group study, team-based learning (TBL), clinically integrated case discussions (CIS) and interactive sessions.
Related Sustainable Development Goals

Course Category	Core Courses	X
	Major Area Courses
	Supportive Courses
	Media and Management Skills Courses
	Transferable Skill Courses

Week	Subjects	Related Preparation
1	Academic and social orientation week: An Overview of the Medical Education Program Introduction to Semester 1 Medical Education Programme & Classroom Rules Methods of assessment Reflection for students Introduction to TBL “Team BASED Learning” and CIS “Clinical Integrated Session” Introduction to Laboratories First Steps to Medicine Introduction to E-med How to Study and Make Effective Use of Your Time Risk Assessment & Laboratory Safety Rules
2	Our Values and medical Education Introduction to medical terminology RIM (Research and Information Management): Introduction and effective feedback, The importance of critical thinking Practical: Introduction to Laboratory processes Biophysical basis of life Biochemical basis of life Principles of electromagnetic radiation (EMR) Medical Applications of EMR Human as a whole from a biopsychological point of view Introduction to the basis of radiological imaging Risk Assessment- Blackboard test	Recep Mesut, Selman Çıkmaz, Tıbbi Terminoloji, 2017, 1-412 Recep Mesut, Selman Çıkmaz, Tıbbi Terminoloji, 2017, 1-412 -Stearns and Medzhitov -Evolutionary Medicine, Sinauer Assoc., 2016, Chapter 3, 87-91 -Laposata M. Laboratory Medicine 2nd Ed. McGraw Hill Access Medicine, 2014, Chapter 1, 6-7 - Biophysics-An introduction Cotteril & al); Chapter 1. - Biophysics-An introduction Cotteril & al); related chapters
3	Organization of the human body: Macroscopic Organization of the human body: Microscopic Superficial anatomical structures of the skeletal system The theory of evolution and the development of living things Effective Learning Q&A Session RIM: The basics of scientific thinking	-Keith L. Moore, Anne M. R. Agur, Arthur F. Dalley, Clinically Oriented Anatomy 7th Ed. 2014, 2-57 -Richard L. Drake, A. Wayne Vogl, Adam W. M. Mitchell, Gray's Anatomy for Students: With STUDENT CONSULT Online Access, 3rd Ed. 2015, 12-48 -Barbara Young, Geraldine O'Dowd, Phillip Woodford, Wheater's Functional Histology: A Text and Colour Atlas, FUNCTIONAL HISTOLOGY (WHEATER'S) 6th Ed. 2014, 31 VOET’s Principles of Biochemistry, Global Edition 2016, 1-23. -Stearns and Medzhitov, Evolutionary Medicine, Sinauer Assoc., 2016, Chapter 1. 1-6
4	General considerations of the skeletal system (bones and joints) Bones and joints of the axial skeleton Bones and joints of the appendicular skeleton Comparative anatomy and embryology Anatomy Lab: Bones and joints of the axial skeleton Chemical bonds and functional groups in biomolecules Types of chemical reactions Cell theory, historical overview of the cell Light and optics Optics-Small group activity The tree of life and prokaryotic and eukaryotic cells Anatomy Lab: Bones and joints of the appendicular skeleton	- Alberts, Johnson, Lewis, Raff, Molecular Biology of the Cell, 6th Ed. 2015, Chapter 1, 1-22. - Rodwell VW, Bender DA, Botham RM, Kennelly PJ, Weil PA. Harper’s Illustrated Biochemistry, 30th Ed. Lange. 2015, Chapter 2, 7-17 - Keith L. Moore, Anne M. R. Agur, Arthur F. Dalley, Clinically Oriented Anatomy 7th Ed. 2014, 71-173; 326-428; 439-501; 508-656; 670-812; 820-973; 981-1051 - Richard L. Drake, A. Wayne Vogl, Adam W. M. Mitchell, Gray's Anatomy for Students: With STUDENT CONSULT Online Access, 3rd Edition. 2015, ;ilgili konular - Stearns and Medzhitov Evolutionary Medicine, Sinauer Assoc. 2016, Chapter 2. 79-84 - Alberts, Johnson, Lewis, Raff, Molecular Biology of the Cell, 6th Edition. 2015, Chapter 1; 23-27. - R.Paul, L.Elder. The Miniature Guide to Critical Thinking-Concepts &Tools. pp 2-8
5	Laboratory Medicine: Basic Concepts in Laboratory Medicine Biophysics devices Biophysics- the future of medicine Ergonomy RIM: Reaching reliable sources Classification of microorganisms, morphology and cell structure Cell sizes and cell shapes Cell and tissue examination methods Practical: The basics of microscopy Anatomy Lab: Skeletal System Discussion Practical: Bacterial cell structure and staining	- Webster (Khlebnikova), E. Statistical Analysis in Analytical Method Validation 2013; IVT Network; http://www.ivtnetwork.com/author/eugenie-webster-khlebnikova (Erişim Tarihi) 26.11.2017) - P.C. Meier and R.E. Zünd. Statistical Methods in Analytical Chemistry, 2nd ed. John Wiley & Sons, New York, 2000. - Laposata. Web center of social research methods/ relability and validity (http://www.socialresearchmethods.net/kb/relandval.php) - Jawetz Melnick & Adelbergs Medical Microbiology 26/E. Geo. Brooks, 2013, Chapter 3, 44-54, Chapter 10, 165-172 Ryan and Ray Sherris Medical Microbiology, 2014, Chapter 1 4-5 - Levinson Review of Medical Microbiology and Immunology 13th Ed. 2014, Chapter 1, 2 4-13, - Michael H. Ross, Wojciech Pawlina, Histology: A Text and Atlas, with Correlated Cell and Molecular Biology, 6th Ed., 2016, 11-21 - Ryan and Ray, Sherris Medical Microbiology, 2014, Chapter 1, 6-12
6	MIDTERM-1 Interaction of elements and molecules Solutions and buffers Biophysics and thermodynamics The basic building blocks of life: macromolecules RIM: Literature search-I Practical: Solution preparation and spectrometry Carbohydrates Fatty Acids Complex lipids	- Rodwell VW, Bender DA, Botham RM, Kennelly PJ, Weil PA. Harper’s Illustrated Biochemistry, 30th Ed, Lange. 2015, Chapter 2, 7-17 - Lieberman M, Peet A. Marks' essentials of medical biochemistry :a clinical approach / 2015 : Second edition. Chapters 3 and 4, 31-59 - Biophysics, AnI Introduction. R.M.J. Cotterill, John Wiley & Sons Ltd. 2nd edition, West Sussex. - Rodwell VW, Bender DA, Botham RM, Kennelly PJ, Weil PA. Harper’s Illustrated Biochemistry, 30th Ed, Lange. 2015, Chapters 3, 4, 5, 14 and 15, 17-48, 85-86, 132-151.
7	Amino acids-Protein building blocks Reactions of amino acids-peptides Protein structure and structure-function relationship Proteopedia-3-D protein modeling practice RIM: Literature search-II Practical: From monomers to macromolecules Life as a compartmentalized system Introduction to cellular metabolism Biochemistry of the extracellular matrix Cell membrane organization TBL (Cell Biochemistry) Meeting with advisors	- Rodwell VW, Bender DA, Botham RM, Kennelly PJ, Weil PA. Harper’s Illustrated Biochemistry, 30th Ed, Lange. 2015, Chapters 3, 4, 5, 14 and 15, 17-48, 85-86, 132-151 - Lieberman M, Peet A. Marks' essentials of medical biochemistry :a clinical approach / 2015 : Second edition. Chapters 3 and 4, 31-59 - VOET’S Principles of Biochemistry, Gobal Edition, 448-449
8	Overview of biological membrane structures and membrane transport Membrane transport: passive and active transport Overview of cell- cytosol and organelles Overview of the cell ultrastructure Enzymes: General Characteristics, cofactors, co-enzymes, and isoenzymes Practical: Membrane and proteins (Modeling) Practical: Osmosis Organization of the cytoskeleton RIM: Application of reaching reliable sources and literature search Co-enzymes, cofactors, and isoenzymes Inhibition and activation of enzymes Regulation of Enzymes Practical: Catalase enzyme activity Case Discussion/Problems on Enzymes	- Michael H. Ross, Wojciech Pawlina, Histology: A Text and Atlas, with Correlated Cell and Molecular Biology, 6th Ed, 2016, 23-26; 26-36 - Rodwell VW, Bender DA, Botham RM, Kennelly PJ, Weil PA. Harper’s Illustrated Biochemistry, 30th Ed, Lange. 2015, Chapters 7, 8, 9 , 57-93, Chapter 48, 589-601 - Alberts, Johnson, Lewis, Raff, Molecular Biology of the Cell, 6th Ed. 2015, Chapter 10, 11, 12; 565-611; 641-649
9	Nucleus, nucleolus From nucleotides to nucleic acids An overview of human genome Genetic information flow – from DNA to protein synthesis- Central dogma Practical: Genomic DNA isolation Replication, Transcription, Translation Gene Expression: Epigenetics Approach Gene expression and arrangements Bacterial genetics(DNA transfer) TBL (Team Based Learning): The Cell General Discussion	- Michael H. Ross, Wojciech Pawlina, Histology: A Text and Atlas, with Correlated Cell and Molecular Biology, 6th Ed. 2016, 26-35; 36-44; 54-55 - Rodwell VW, Bender DA, Botham RM, Kennelly PJ, Weil PA. Harper’s Illustrated Biochemistry, 30th Ed, Lange. 2015, Chapters 32 and 34, 323-331, 343-354 Jawetz Melnick & Adelbergs Medical Microbiology 26/E. Geo. Brooks, 2013, Chapter 7, 101-122 - Kim E. Barrett, Medical Physiology Ganong. 2012 - Alberts, Johnson, Lewis, Raff, Molecular Biology of the Cell, 6th Ed. 2015, Chapter 4, 5, 6, 12; 175-216; 237-265; 299-362; 649-694 - Thompson & Thompson Genetics in Medicine, 8th Edition. Nussbaum, McInnes, Willard, 2016. Chapter 2, 3; 3-11; 21-41 - Peter Turnpenny, Sian Ellard, Emery’s Elements of Medical Genetics, 14th Ed. 2012, Chapter 2, 13-22
10	MIDTERM-2 Intracellular compartment: Endoplasmic Reticulum Structure and function of Golgi & Post-translational modifications Structures and functions of lysosome, peroxisome, proteosome and inclusions Transport into the cell through the membrane and transport out of the cell from Trans-Golgi Network Practical: PCR and Gel Electrophoresis-I Structure and functions of mitochondria Glycolysis: A metabolic pathway of the cell cytoplasm Kreb's cycle Oxydative phosphorylation Cell signaling-I Cell signaling-II Lab Med: Precision and accuracy in Laboratory Medicine Practical: PCR and Gel Electrophoresis-II	- Michael H. Ross, Wojciech Pawlina, Histology: A Text and Atlas, with Correlated Cell and Molecular Biology, 6th Ed. 2016, 36-44; 55-69 - Rodwell VW, Bender DA, Botham RM, Kennelly PJ, Weil PA. Harper’s Illustrated Biochemistry, 30th Ed. Lange, 2015, Chapters 16,17, and 18, 151-177 - Kim E. Barrett, Medical Physiology Ganong. 2012 - Alberts, Johnson, Lewis, Raff, Molecular Biology of the Cell, 6th Ed. 2015, Chapter 10, 13, 14, 15, 16, 17; 590-593; 695-752; 753-758; 813-880; 889-960; 963- 977. -Jawetz Melnick&Adelbergs Medical Microbiology, 26/E. Geo. Brooks, 2013 Chapter 6, 77-99 -Skloot R, The Immortal Life of Henrietta Lacks, 2011
11	Membrane Potential Cell signaling-III Distribution of action potential, excitation and excitable tissues Cell Signaling: Clinically- Integrated Discussion Session Cell Cycle and Control Mechanisms Cell Division (mitosis and meiosis) Practical: Action potential Mechanisms of cell death and apoptosis Cell Differentiation Genetic variation: polymorphisms and mutations Inheritance patterns The molecule of the Century Practical: Cell division	-Michael H. Ross, Wojciech Pawlina, Histology: A Text and Atlas, with Correlated Cell and Molecular Biology, 6th Ed. 2016, 100-104; 105-149 -T.W.Sadler, Langman’s Medical Embriyology, 13th Ed. 2015, 3-10 - Rodwell VW, Bender DA, Botham RM, Kennelly PJ, Weil PA. Harpr’s Illustrated Biochemistry, 30th Ed. Lange, 2015, Chapter 48, 589-608 - Kim E. Barrett, Medical Physiology Ganong. 2012 - Alberts, Johnson, Lewis, Raff, Molecular Biology of the Cell, 6th Ed. 2015, Chapter 17, 18, 19; 978-1020; 1021-1034; 1035-1056 - Peter Turnpenny, Sian Ellard, Emery’s Elements of Medical Genetics, 14th Ed. 2012, Chapter 3; 38-41
12	Pedigree-the basics Population Genetics Population Genetics –Case Study Chromosome Nomenclature and Cytogenetics Inheritance patterns-Practical Constructing a Pedigree Practical: Cytogenetics Tissue types - General structural properties of 4 basic tissues Epithelial tissue types Intercellular connections in the epithelial tissue Cell surface specializations Secretory epithelium (serous and mucous secretory cells) Practical: Types of epithelial tissue Practical: Cell Culture	- Keith L. Moore, T. V. N. Persaud, Mark G. Torchia, The Developing Human: Clinically Oriented Embryology, 10th Ed. 2016, 99; 457-485 -T.W.Sadler, Langman’s Medical Embriyology, 13th Ed, 2015, 126-139 - Nussbaum, McInnes, Willard, Thompson & Thompson Genetics in Medicine, 8th Ed. 2016. Chapter 4, 5, 7, 9, 14; 43-57; 57-75; 107-128; 155-163; 283-287. - Peter Turnpenny, Sian Ellard, Emery’s Elements of Medical Genetics, 14th Ed. 2012, Chapter 2, 3, 7, 8, 9, 16; 22-29;31-53; 109-129; 129-142; 143-154; 249-263. Michael H. Ross, Wojciech Pawlina, Histology: A Text and Atlas, with Correlated Cell and Molecular Biology, 6th Ed. 2016, 100-104; 105-149 -T.W.Sadler, Langman’s Medical Embriyology, 13th Ed. 2015, 3-10 - Kim E. Barrett, Medical Physiology Ganong. 2012 - Peter Turnpenny, Sian Ellard, Emery’s Elements of Medical Genetics, 14th Ed. 2012, Chapter 3; 38-41
13	MIDTERM-3 Organization of connective tissue Types of connective tissue Molecular overview of connective tissue Structure of connective tissue and its cells Practical: Types of connective tissue Structure of cartilage tissue Structure of bone tissue Bone tissue and ossification Structure of muscle tissue and muscle types Nervous tissue - general structural and functional features Practical: Types of cartilage and bone tissues Practical: Molecular biophysics	- Michael H. Ross, Wojciech Pawlina, Histology: A Text and Atlas, with Correlated Cell and Molecular Biology, 6th Ed. 2016, Chapter 6,7,8,11,12 156-174; 194-203; 214-239; 314-340; 356-389 - Michael H. Ross, Wojciech Pawlina, Histology: A Text and Atlas, with Correlated Cell and Molecular Biology, 6th Ed. 2016, Chapter 22, 23, 797; 834. - Rodwell VW, Bender DA, Botham RM, Kennelly PJ, Weil PA. Harper’s Illustrated Biochemistry, 30th Ed. Lange, 2015, Chapter 48, 589-608
14	Gametogenesis: Spermatogenesis Gametogenesis: Oogenesis RIM: Discussion Session Ovulation and menstrual cycle From fertilization to implantation Bilaminar germ disc Practical: Muscle and nervous tissues Practical: Bacterial Growth Curve	- Michael H. Ross, Wojciech Pawlina, Histology: A Text and Atlas, with Correlated Cell and Molecular Biology, 6th Ed. 2016, Chapter 22, 23, 797; 834. - Keith L. Moore, T. V. N. Persaud, Mark G. Torchia, The Developing Human: Clinically Oriented Embryology, 10th Ed. 2016, 11-38; 39-49; 51-59 - Alberts, Johnson, Lewis, Raff, Molecular Biology of the Cell, 6th Ed. 2015, Chapter 22, 1217-1247.
15	Gastrulation: Trilaminar germ disc Embryonic period Teratogens Fetal Period Extra embryonic tissues The History and impact of Genetics in Medicine Recombinant DNA Technologies Practical: Ovulation-Fertilization-Embryo Implantation	- Keith L. Moore, T. V. N. Persaud, Mark G. Torchia, The Developing Human: Clinically Oriented Embryology, 10th Ed. 2016, 99; 457-485 -T.W.Sadler, Langman’s Medical Embriyology, 13th Ed, 2015, 126-139 - Nussbaum, McInnes, Willard, Thompson & Thompson Genetics in Medicine, 8th Ed. 2016. Chapter 4, 5, 7, 9, 14; 43-57; 57-75; 107-128; 155-163; 283-287 - Peter Turnpenny, Sian Ellard, Emery’s Elements of Medical Genetics, 14th Ed. 2012, Chapter 2, 3, 7, 8, 9, 16; 22-29;31-53; 109-129; 129-142; 143-154; 249-263 - T.W.Sadler, Langman’s Medical Embriyology, 13th Ed, 2015, 126-139
16	CIS General Discussion Workload Evaluation (For Bologna & Feedback) MIDTERM-4

Course Notes/Textbooks

Keith L. Moore, Anne M. R. Agur, Arthur F. Dalley, Clinically Oriented Anatomy 7^th Ed. 2014
Gavin Frances, Adventures in Human Being: A grand Tour from the Cranium to the Calcaneum, 1^st edition, 2015
Kim E. Barrett, Ganong’s Medical Physiology, 25e, 2016
Michael H. Ross, Wojciech Pawlina, Histology: A Text and Atlas, with Correlated Cell and Molecular Biology, 6^th Ed. 2016
Keith L. Moore, T. V. N. Persaud, Mark G. Torchia, The Developing Human: Clinically Oriented Embryology, 10^th Ed. 2016
Thomas W. Sadler, Langman’s Medical Embryology, Thirteenth North American edition, 2015
Rodwell VW, Bender DA, Botham RM, Kennelly PJ, Weil PA, Harper’s Illustrated Biochemistry, Lange. 30^th Ed. 2015
Michael Lieberman & Alisa Peet, MARKS’ Basic Medical Biochemistry: A Clinical Approach, Fifth, North American Edition, 2018
Michael W. King, Intergrative Medical Biochemistry Examination and Board Review, 2014
Barbara Young,Geraldine O’Dowd, Phillip Woodford, Wheater’s Functional Histology: A Text and Colour Atlas, 6th edition,2014
Alberts, Johnson, Lewis, Raff, Molecular Biology of the Cell, 6^th Ed. 2015
Peter Turnpenny, Sian Ellard, Emery’s Elements of Medical Genetics, 14^th Ed. 2012
Nussbaum, McInnes, Willard, Thompson & Thompson Genetics in Medicine, 8^th Ed. 2016
Laposata M. Laboratory Medicine, McGraw Hill Access Medicine, 2^nd Ed., 2014
Jawetz Melnick&Adelbergs Medical Microbiology, 26/E. Geo. Brooks, 2013
Stearns and Medzhitov, Evolutionary Medicine, Sinauer Assoc, 2015
Ryan and Ray Sherris, Medical Microbiology, McGraw Hill Access Medicine
Levinson Review of Medical Microbiology and Immunology, 14^th Ed. 2016

Suggested Readings/Materials

Recep Mesut, Selman Çıkmaz, Tıbbi Terminoloji, 2017
Hal Blumenfeld, Neuroanatomy Through Clinical Cases, Second Edition, Text with Interactive eBook, 2010
Richard L. Drake, A. Wayne Vogl, Adam W. M. Mitchell, Gray's Anatomy for Students: With STUDENT CONSULT Online Access, 3^rd Ed. 2015
LW Janson & ME Tischler, The Big Picture: Medical Biochemistry, 2012
Linda Costanzo, Physiology Cases and Problems (Board Review Series), 4^th Ed. 2012
Jonathan D. Kibble and Colby R.Halsey, Medical Physiology, The Big Picture, 2009
Barbara Young, Geraldine O'Dowd, Phillip Woodford, Wheater's Functional Histology: A Text and Colour Atlas, 6e (FUNCTIONAL HISTOLOGY (WHEATER'S)) 6^th Ed. 2014
Thomas W. Sadler, Langman's Medical Embryology 13^thNorth American Ed. 2015
Alberts, Johnson, Lewis, Raff, Molecular Biology of the Cell, 2015
Clinical Biochemistry, An Illustrated Colour Text. Gaw, Murphy, Srivastava, 2013
Skloot R, The Immortal Life of Henrietta Lacks, 2011
Linda Costana,Physiology Cases and Problems (Board Review Series) Fourth Edition, 2012

Semester Activities	Number	Weigthing
Participation
Laboratory / Application
Field Work
Quizzes / Studio Critiques
Portfolio	1	10
Homework / Assignments	1	10
Presentation / Jury
Project
Seminar / Workshop
Oral Exams
Midterm	4	40
Final Exam	1	40
Total

Weighting of Semester Activities on the Final Grade	6	60
Weighting of End-of-Semester Activities on the Final Grade	1	40
Total

Semester Activities	Number	Duration (Hours)	Workload
Theoretical Course Hours (Including exam week: 16 x total hours)	16	12	192
Laboratory / Application Hours (Including exam week: '.16.' x total hours)	16	4	64
Study Hours Out of Class	16	5	80
Field Work			0
Quizzes / Studio Critiques			0
Portfolio	1	10	10
Homework / Assignments	2	8	16
Presentation / Jury			0
Project			0
Seminar / Workshop			0
Oral Exam			0
Midterms	4	20	80
Final Exam	1	38	38
		Total	480

#	Program Competencies/Outcomes	* Contribution Level
#	Program Competencies/Outcomes	1	2	3	4	5
1	Knowledge of medical practices: Utilizes knowledge from basic and clinical medical sciences, epidemiology, biostatistics, biomedical informatics, and social and behavioral sciences to prevent, diagnose, treat, and manage medical problems.	-	-	-	X	-
2	Competence in professional skills: Competence in Professional Skills: Possesses the basic medical skills and attitude necessary for practicing the profession, understands personal limits, evaluates own performance, identifies areas needing improvement, and implements these improvements within a plan.	X	-	-	-	-
3	Patient Management: Provides patient-centered, holistic, safe, reliable, fair, and evidence-based healthcare services, prioritizing the protection and promotion of health, especially for the primary health issues in the community. Seeks support from other healthcare professionals and institutions when necessary, following the referral chain.	-	-	-	-	-
4	Patient and Employee Safety: Delivers healthcare services with consideration for the health and safety of both patients and healthcare workers throughout diagnosis, treatment, and rehabilitation processes.	X	-	-	-	-
5	Planetary Health and Healthy Lifestyles: Considers the impact of the planet's resources on individual and community health in professional practices. Takes it as a duty to inform the public, promote healthy lifestyles, and eliminate factors that negatively affect health.	-	-	-	-	-
6	Information Management and Research: Explains the role and importance of scientific research and evidence in delivering high-quality and safe healthcare services. Analyzes health issues in the community using scientific methods. Utilizes information generated through research and accessed from accurate, reliable sources, by appropriately using information technologies, in evidence-based patient management processes.	-	-	-	X	-
7	Adherence to Ethical Principles: Fulfills duties and responsibilities within the framework of ethical principles, rights, and legal obligations required by the profession, considering good medical practices and deontology principles. Recognizes ethical dilemmas and can analyze and make decisions accordingly.	-	-	-	-	-
8	Professional Virtues: Avoids behaviors that could undermine public trust in the medical profession. Approaches patients with compassion, care, and empathy without discrimination, prioritizing their well-being over personal interests. Ensures the confidentiality and privacy of patient information.	X	-	-	-	-
9	Health Policies and Advocacy: Assesses the impact of health policies on the health indicators of individuals and communities. Advocates for the development of healthcare services in line with social reliability and responsibilities.	-	-	-	-	-
10	Protecting and Promoting Health as a Social Responsibility: Accepts the protection and promotion of community health as a social responsibility, identifies priority health issues in the community served, develops solutions, and provides health education and counseling services.	X	-	-	-	-
11	Protecting and Promoting Health in Extraordinary Situations: Prioritizes the protection and promotion of individual and community health during extraordinary situations. Performs clinical and public health practices in a comprehensive and competent manner.	-	-	-	-	-
12	Healthy Physician - Healthy Community: Pays attention to personal health, hygiene, safety, and appearance. Explains and implements measures for maintaining health, strategies for coping with stress, and preventing burnout to maintain a healthy life. Sets an example for colleagues and the community through personal practices.	-	-	-	-	-
13	Change Management and Leadership: Systematically identifies issues and processes requiring change to provide high-quality, safe, and cost-effective healthcare services, along with the necessary resources. Acquires the skills to lead these changes effectively.	X	-	-	-	-
14	Teamwork: Establishes positive communication with healthcare professionals and other occupational groups. Demonstrates effective feedback practices, adopts a supportive approach, understands and fulfills personal rights, duties, and responsibilities in a timely and appropriate manner, and takes on different team roles as needed.	X	-	-	-	-
15	Communication Skills: Effectively uses written, verbal, and non-verbal communication.	X	-	-	-	-
16	Communication for Qualified and Safe Healthcare: Engages with patients, their families, healthcare professionals, other occupational groups, institutions, and organizations to minimize patient safety risks, enhance the quality of healthcare, in clear, understandable, and professionally appropriate communication while involving patients in decision-making processes, and considering potential differences and needs while providing necessary information.	X	-	-	-	-
17	Lifelong Learning: Uses self-assessment approaches to evaluate professional performance, identifies areas needing improvement, determines learning needs, and organizes personal learning processes to enhance professional knowledge and skills.	X	-	-	-	-